Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CPA3 | P15088 | 3/20 | 0.50 |
| ▸ | CPA1 | P15085 | 6/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.49 |
| ▸ | CPB1 | P15086 | 1/20 | 0.49 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.48 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28106233 | 1.00 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL28576210 | 0.87 | CSNK1E (0.54) | FOLH1 | |
| SCHEMBL18637644 | 0.86 | CYP1A2 (0.52) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL1709339 | 0.85 | CYP1A2 (0.64) | CYP1A2CPA3CPA1FOLH1CPB1 | |
| SCHEMBL4550704 | 0.85 | CYP1A2 (0.70) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL6657008 | 0.85 | CYP1A2 (0.70) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL1709283 | 0.85 | CYP1A2 (0.64) | CYP1A2CPA3CPA1FOLH1CPB1 | |
| SCHEMBL5710051 | 0.85 | CYP1A2 (0.59) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL14520756 | 0.84 | HDAC3 (0.59) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL13933742 | 0.82 | ANPEP (0.52) | CYP1A2CPA3CPA1FOLH1CPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109970797-A | Hydroxyformamide derivatives and application thereof | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-106103431-B | Hydroxycarboxamide derivatives and their use | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-106103431-A | Hydroxycarboxamide derivatives and their use | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2016-11-09 | — | — | CN | disclosed |