Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.47 |
| ▸ | OTC | P00480 | 1/20 | 0.46 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.43 |
| ▸ | NOS2 | P35228 | 5/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 4/20 | 0.41 |
| ▸ | NOS1 | P29475 | 4/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | ARG1 | P05089 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL5586520 | 0.95 | PTGS1 (0.52) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL27769534 | 0.95 | PTGS1 (0.52) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL3487127 | 0.95 | PTGS1 (0.52) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL3487131 | 0.95 | PTGS1 (0.52) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL9756053 | 0.92 | OTC (0.51) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| Arginine SCHEMBL2421556 | 0.92 | OTC (0.51) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| L-Citrulline SCHEMBL6930186 | 0.92 | PTGS1 (0.55) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL2421554 | 0.92 | OTC (0.51) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| L-Citrulline SCHEMBL6930182 | 0.92 | PTGS1 (0.55) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL27607453 | 0.92 | OTC (0.51) | OTCDDAH1NOS2CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106029084-A | Method of treating acute myeloid leukemia with FMS-like tyrosine kinase 3 mutation | 百欧肯治疗有限公司 | 2016-10-12 | — | — | CN | disclosed |