Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.55 |
| ▸ | OTC | P00480 | 1/20 | 0.51 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.48 |
| ▸ | NOS2 | P35228 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 3/20 | 0.41 |
| ▸ | NOS1 | P29475 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ARG2 | P78540 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Citrulline SCHEMBL6930182 | 1.00 | PTGS1 (0.55) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL28106594 | 0.92 | PTGS1 (0.47) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| L-Citrulline SCHEMBL4542892 | 0.91 | OTC (0.59) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| L-Citrulline SCHEMBL22426116 | 0.91 | OTC (0.59) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| L-Citrulline SCHEMBL15909605 | 0.91 | OTC (0.59) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| L-Citrulline SCHEMBL20587 | 0.91 | OTC (0.59) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| L-Citrulline SCHEMBL15909604 | 0.91 | OTC (0.59) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| L-Citrulline SCHEMBL215403 | 0.91 | OTC (0.59) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| L-Citrulline SCHEMBL437142 | 0.91 | OTC (0.59) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| L-Citrulline SCHEMBL9070200 | 0.91 | OTC (0.59) | OTCDDAH1NOS2CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831703-A4 | METHOD OF SOLUBILIZING AND ENCAPSULATING ITRACONAZOLE | EMISPHERE TECH INC (US) | 2003-05-21 | — | — | EP | disclosed |
| US-20030042638-A1 | Method of solubilizing and encapsulating itraconazole | KANTOR MARTIN L (US) | 2003-03-06 | — | — | US | disclosed |
| US-6461545-B1 | Method of solubilizing and encapsulating itraconazole | EMISPHERE TECHNOLOGIES, INC. | 2002-10-08 | — | — | US | disclosed |
| US-6100285-A | SOLUTION OF ITRACONAZOLE DISSOLVED IN VOLATILE ORGANIC ACID SOLVENT; BIOAVAILABILITY | EMISPHERE TECHNOLOGIES, INC. (US) | 2000-08-08 | — | — | US | disclosed |
| US-5750147-A | FUNGICIDES FOR ORAL ADMINISTRATION | EMISPHERE TECHNOLOGIES, INC. (US) | 1998-05-12 | — | — | US | disclosed |
| EP-0831703-A1 | METHOD OF SOLUBILIZING AND ENCAPSULATING ITRACONAZOLE | Emisphere Technologies, Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039835-A1 | METHOD OF SOLUBILIZING AND ENCAPSULATING ITRACONAZOLE | EMISPHERE TECHNOLOGIES, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0666729-A1 | COSMETIC COMPOSITION | UNILEVER PLC (GB) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994009750-A1 | COSMETIC COMPOSITION | UNILEVER PLC (GB) | 1994-05-11 | — | — | WO | disclosed |