Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.52 |
| ▸ | OTC | P00480 | 1/20 | 0.49 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.46 |
| ▸ | NOS2 | P35228 | 6/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 5/20 | 0.44 |
| ▸ | NOS1 | P29475 | 5/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ARG1 | P05089 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL3487127 | 1.00 | PTGS1 (0.52) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL3487131 | 1.00 | PTGS1 (0.52) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL27769534 | 1.00 | PTGS1 (0.52) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL28106594 | 0.95 | PTGS1 (0.47) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL28213703 | 0.94 | PTGS1 (0.46) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL20678167 | 0.94 | PTGS1 (0.46) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL16637167 | 0.94 | PTGS1 (0.46) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL1507561 | 0.94 | PTGS1 (0.46) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL16970950 | 0.93 | CYP1A2 (0.50) | PTGS1SLC7A11OTCDDAH1NOS2 | |
| Arginine SCHEMBL16970951 | 0.93 | CYP1A2 (0.50) | PTGS1SLC7A11OTCDDAH1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499303-A4 | MULTI-PHASE, MULTI-COMPARTMENT CAPSULAR SYSTEM | MILLER FRED H (US) | 2007-07-25 | — | — | EP | disclosed |
| EP-1499303-A2 | MULTI-PHASE, MULTI-COMPARTMENT CAPSULAR SYSTEM | Miller, Fred H. (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086267-A2 | MULTI-PHASE, MULTI-COMPARTMENT CAPSULAR SYSTEM | MILLER FRED H (US) | 2003-10-23 | — | — | WO | disclosed |