Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28106815 | 0.86 | MEN1 (0.51) | PTGS2PTGS1PAX8MEN1KMT2A | |
| SCHEMBL1736457 | 0.83 | PAX8 (0.57) | PAX8MEN1KMT2ARAB9ATRPV1 | |
| SCHEMBL444703 | 0.80 | ALDH1A1 (0.53) | PTGS2PTGS1MEN1KMT2ARAB9A | |
| SCHEMBL1736168 | 0.80 | MEN1 (0.57) | MEN1KMT2ARAB9ATRPV1PDE10A | |
| SCHEMBL1738384 | 0.80 | MAPT (0.52) | MEN1KMT2ARAB9ATRPV1PDE10A | |
| SCHEMBL27930436 | 0.80 | TRPV1 (0.51) | PAX8MEN1KMT2ARAB9ATRPV1 | |
| SCHEMBL28567279 | 0.79 | PDE10A (0.50) | PAX8MEN1KMT2ARAB9ATRPV1 | |
| SCHEMBL1738423 | 0.79 | NPC1 (0.56) | MEN1KMT2ARAB9ATRPV1PDE10A | |
| SCHEMBL1735377 | 0.79 | TRPV1 (0.51) | PAX8MEN1KMT2ARAB9ATRPV1 | |
| SCHEMBL31451585 | 0.79 | NPC1 (0.56) | MEN1KMT2ARAB9ATRPV1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106029663-A | Tricyclic compounds as anticancer agents | 百时美施贵宝公司 | 2016-10-12 | — | — | CN | disclosed |