Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16982335 | 0.84 | L3MBTL1 (0.51) | LMNASMN1; SMN2ALDH1A1GAAHPGD | |
| SCHEMBL28107004 | 0.77 | MAPK1 (0.58) | LMNAMAPK1ALDH1A1MAPTVCAM1 | |
| SCHEMBL16982489 | 0.74 | L3MBTL1 (0.52) | ALDH1A1GAAHPGDSIRT6BLM | |
| SCHEMBL31003858 | 0.74 | CASP6 (0.63) | LMNA | |
| SCHEMBL16974724 | 0.74 | CASP6 (0.63) | LMNA | |
| SCHEMBL20225770 | 0.74 | MEN1 (0.54) | LMNASMN1; SMN2MAPK1ALDH1A1MAPT | |
| SCHEMBL11456145 | 0.72 | SMN1; SMN2 (0.82) | LMNASMN1; SMN2MAPK1ALDH1A1MAPT | |
| SCHEMBL3988487 | 0.71 | AR (0.54) | LMNAALDH1A1MAPTVCAM1HPGD | |
| SCHEMBL31003842 | 0.71 | AR (0.54) | LMNAALDH1A1MAPTVCAM1HPGD | |
| Hydrochloric Acid SCHEMBL11726620 | 0.71 | SMN1; SMN2 (0.80) | LMNASMN1; SMN2MAPK1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105980388-A | Compound (I) | 葛兰素史密斯克莱知识产权发展有限公司 | 2016-09-28 | — | — | CN | disclosed |