Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | GCGR | P47871 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21803709 | 0.84 | GCGR (0.52) | PTGS2SLC22A12PDE2APDE10AGCGR | |
| SCHEMBL17795041 | 0.83 | CYP11B1 (0.53) | CYP11B1CYP11B2PTGS2SLC22A12ABL1 | |
| SCHEMBL14900842 | 0.83 | CYP11B1 (0.51) | CYP11B1CYP11B2PTGS2SLC22A12ABL1 | |
| SCHEMBL527072 | 0.82 | PTGS2 (0.50) | CYP11B1CYP11B2PTGS2SLC22A12ABL1 | |
| SCHEMBL28279885 | 0.81 | RPS6KA3 (0.63) | PTGS2SLC22A12GCGRMAPK14LIMK1 | |
| SCHEMBL20437882 | 0.81 | CYP11B1 (0.47) | CYP11B1CYP11B2PTGS2ABL1CYP17A1 | |
| SCHEMBL526758 | 0.80 | ALDH1A1 (0.61) | PTGS2CYP17A1 | |
| SCHEMBL16455592 | 0.80 | CYP17A1 (0.55) | CYP11B1CYP11B2PTGS2SLC22A12ABL1 | |
| SCHEMBL17864528 | 0.80 | CYP11B1 (0.50) | CYP11B1CYP11B2PTGS2ABL1CYP17A1 | |
| SCHEMBL10272837 | 0.80 | ABL1 (0.55) | CYP11B1CYP11B2PTGS2SLC22A12ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110452216-A | Anti-fibrosis pyridinone | INTERMUNE INC | 2019-11-15 | — | — | CN | disclosed |
| CN-106459042-B | Anti-fibrotic pyridinones | 英特穆恩公司 | 2019-06-28 | — | — | CN | disclosed |
| CN-106459042-A | Anti-fibrotic pyridinones | 英特穆恩公司 | 2017-02-22 | — | — | CN | disclosed |