Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.46 |
| ▸ | BRS3 | P32247 | 1/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | HPN | P05981 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9938245 | 0.76 | HCAR2 (0.58) | HCAR2NR4A2 | |
| SCHEMBL28109060 | 0.75 | SRD5A2 (0.47) | KDM5AKDM4CKDM5B | |
| SCHEMBL9937529 | 0.74 | HCAR2 (0.51) | HCAR2BRS3NR4A2DCLRE1BSLC1A1 | |
| SCHEMBL28105342 | 0.72 | HCAR2 (0.52) | HCAR2BRS3NR4A2DCLRE1BSLC1A1 | |
| SCHEMBL28108996 | 0.71 | GABRP (0.50) | LMNA | |
| SCHEMBL1542175 | 0.70 | GABRP (0.53) | POLB | |
| SCHEMBL6856480 | 0.70 | HCAR2 (0.54) | HCAR2BRS3NR4A2KDM5AKDM4C | |
| SCHEMBL28117926 | 0.70 | TSHR (0.57) | HCAR2BRS3NR4A2DCLRE1B | |
| SCHEMBL19662728 | 0.69 | HCAR2 (0.47) | HCAR2NR4A2KDM5AKDM4CKDM5B | |
| SCHEMBL4677 | 0.69 | TAAR1 (0.42) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106146491-B | The naphthyridine compounds of 5 hydroxyl 1,7, its preparation method and its pharmaceutical applications being optionally substituted aryl or heteroaryl | 沈阳三生制药有限责任公司 | 2017-12-12 | — | — | CN | disclosed |
| CN-106146491-A | 5-hydroxyl-1,7-naphthyridine compounds, its preparation method and the pharmaceutical applications thereof being optionally substituted aryl or heteroaryl | 沈阳三生制药有限责任公司 | 2016-11-23 | — | — | CN | disclosed |