Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | CTSG | P08311 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | BID | P55957 | 3/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.36 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.36 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.36 |
| ▸ | IAPP | P10997 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL313686 | 0.95 | PNMT (0.60) | PNMTNPC1RAB9ADRD2DRD4 | |
| SCHEMBL5823386 | 0.91 | PNMT (0.58) | PNMTNPC1RAB9ADRD2DRD4 | |
| SCHEMBL6675428 | 0.89 | PNMT (0.57) | PNMTDRD2DRD4DRD3ALOX5 | |
| SCHEMBL407782 | 0.89 | PNMT (0.57) | PNMTDRD2DRD4DRD3ALOX5 | |
| SCHEMBL28103115 | 0.89 | PNMT (0.57) | PNMTDRD2DRD4DRD3ALOX5 | |
| SCHEMBL29911116 | 0.89 | PNMT (0.57) | PNMTDRD2DRD4DRD3ALOX5 | |
| SCHEMBL6672769 | 0.89 | PNMT (0.57) | PNMTDRD2DRD4DRD3ALOX5 | |
| SCHEMBL1449245 | 0.89 | PNMT (0.57) | PNMTDRD2DRD4DRD3ALOX5 | |
| SCHEMBL28825898 | 0.89 | PNMT (0.57) | PNMTDRD2DRD4DRD3ALOX5 | |
| SCHEMBL14836704 | 0.89 | PNMT (0.57) | PNMTDRD2DRD4DRD3ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106242938-B | Fluorene ethylene derivative and synthetic method thereof | 沈阳大学 | 2019-04-23 | — | — | CN | disclosed |
| CN-106242938-A | Fluorene ethylene derivative and synthetic method thereof | 沈阳大学 | 2016-12-21 | — | — | CN | disclosed |
| CN-106220553-A | Carbazole-fluorene ethylene derivatives and synthetic method thereof | 沈阳大学 | 2016-12-14 | — | — | CN | disclosed |