Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17224828 | 0.84 | PLAU (0.41) | PLAUKDM4EPOLBHCAR2ALDH1A1 | |
| SCHEMBL16711940 | 0.82 | L3MBTL1 (0.42) | PLAUTSHRMAPTPAK1POLB | |
| SCHEMBL18335071 | 0.80 | PLAU (0.43) | PLAUTSHRMAPTKDM4EPOLB | |
| SCHEMBL24852722 | 0.79 | KDM4E (0.38) | MAPTKDM4EPOLBHCAR2ALDH1A1 | |
| SCHEMBL17362509 | 0.79 | HSD17B10 (0.49) | TSHRMAPTKDM4EPOLBALDH1A1 | |
| SCHEMBL23953722 | 0.79 | PLAU (0.37) | PLAUMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL29837373 | 0.78 | ALDH1A1 (0.47) | PLAUKDM4EPOLBHCAR2ALDH1A1 | |
| SCHEMBL362121 | 0.78 | ALDH1A1 (0.47) | PLAUKDM4EPOLBHCAR2ALDH1A1 | |
| SCHEMBL17224852 | 0.78 | PLAU (0.44) | PLAUKDM4EPOLBHCAR2ALDH1A1 | |
| SCHEMBL20613722 | 0.78 | HCAR2 (0.41) | PLAUTSHRMAPTKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106255688-A | Morpholine pyridine derivate | 豪夫迈·罗氏有限公司 | 2016-12-21 | — | — | CN | disclosed |