Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12890771 | 0.87 | KLK5 (0.51) | CTSSCTSKALDH1A1MAPTKDM4E | |
| SCHEMBL30471370 | 0.87 | KLK5 (0.51) | CTSSCTSKALDH1A1MAPTKDM4E | |
| SCHEMBL24390653 | 0.84 | CYP3A4 (0.59) | CTSSCTSKMAPTRAB9ACA2 | |
| SCHEMBL12214475 | 0.84 | CYP3A4 (0.59) | CTSSCTSKMAPTRAB9ACA2 | |
| SCHEMBL26226843 | 0.83 | ALDH1A1 (0.67) | CTSSCTSKALDH1A1MAPTRAB9A | |
| SCHEMBL22137002 | 0.83 | ALDH1A1 (0.67) | CTSSCTSKALDH1A1MAPTRAB9A | |
| SCHEMBL16284648 | 0.83 | ALDH1A1 (0.67) | CTSSCTSKALDH1A1MAPTRAB9A | |
| SCHEMBL27817322 | 0.83 | KDM4E (0.53) | CTSSCTSKALDH1A1MAPTKDM4E | |
| SCHEMBL28232199 | 0.81 | CYP1A2 (0.54) | CTSSALDH1A1MAPTRAB9ACTSL | |
| SCHEMBL11802988 | 0.81 | CTSS (0.49) | CTSSCTSKALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113307772-B | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-113307772-A | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2021-08-27 | — | — | CN | disclosed |
| CN-106257976-B | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2021-02-02 | — | — | CN | disclosed |
| CN-106257976-A | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2016-12-28 | — | — | CN | disclosed |