Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K3 | P46734 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | ILK | Q13418 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8600507 | 0.81 | MKNK1 (0.41) | MAP2K3MAPK14KDM4EALDH1A1GAA | |
| SCHEMBL30542987 | 0.77 | MAP2K3 (0.32) | MAP2K3MAPK14SYK | |
| SCHEMBL1403852 | 0.75 | SIRT3 (0.46) | MAP2K3MAPK14KDM4ENNMTSYK | |
| SCHEMBL15650965 | 0.74 | MAP2K3 (0.50) | MAP2K3MAPK14KDM4EALDH1A1GLA | |
| SCHEMBL18561312 | 0.73 | SYK (0.59) | SYK | |
| SCHEMBL30591940 | 0.72 | MAP2K3 (0.44) | MAP2K3KDM4EALDH1A1NNMTKDM4C | |
| SCHEMBL28309038 | 0.72 | SIRT3 (0.38) | MAP2K3KDM4EALDH1A1P2RX7MEN1 | |
| SCHEMBL3145246 | 0.72 | MAP2K3 (0.44) | MAP2K3KDM4EALDH1A1NNMTKDM4C | |
| SCHEMBL19691158 | 0.72 | KMT2A (0.37) | MAP2K3KDM4EALDH1A1GAAP2RX7 | |
| SCHEMBL22290178 | 0.72 | P2RX7 (0.34) | MAP2K3MAPK14KDM4EALDH1A1NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106187910-A | Pyridazine class derivant and its production and use | 浙江大学 | 2016-12-07 | — | — | CN | claimed |
| CN-106187910-A | Pyridazine class derivant and its production and use | 浙江大学 | 2016-12-07 | — | — | CN | disclosed |