Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 9/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | PLEC | Q15149 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | AOC1 | P19801 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28111204 | 0.81 | MAP2K3 (0.50) | SYKKDM4EALDH1A1GAALRRK2 | |
| SCHEMBL28051960 | 0.77 | MKNK1 (0.50) | MKNK1MKNK2KDM4EALDH1A1HPGD | |
| SCHEMBL18992945 | 0.75 | MKNK1 (0.40) | MKNK1MKNK2SYKKDM4EALDH1A1 | |
| SCHEMBL22290178 | 0.75 | P2RX7 (0.34) | SYKKDM4EALDH1A1HPGDLRRK2 | |
| SCHEMBL27202091 | 0.75 | IKBKB (0.34) | SYKKCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL30542987 | 0.73 | MAP2K3 (0.32) | SYKMAP2K3MAPK14 | |
| SCHEMBL16506569 | 0.72 | GAA (0.40) | MKNK1MKNK2SYKKCNH2KDM4E | |
| SCHEMBL1403852 | 0.71 | SIRT3 (0.46) | MKNK1MKNK2SYKKDM4ELRRK2 | |
| SCHEMBL11825782 | 0.70 | AOC1 (0.38) | KCNH2KDM4EALDH1A1HPGDGAA | |
| SCHEMBL29088329 | 0.70 | IKBKB (0.46) | MKNK1MKNK2ALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0847391-A1 | AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZENECA LIMITED (GB) | 1998-06-17 | — | — | EP | disclosed |
| WO-1997000864-A1 | AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZENECA LIMITED (GB) | 1997-01-09 | — | — | WO | disclosed |