SCHEMBL28111240

SCHEMBL28111240

COc1c(CN)[c]cc(Br)c1OC

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CA2 P00918 4/20 0.41
CA4 P22748 4/20 0.41
CA1 P00915 2/20 0.35
CA6 P23280 2/20 0.35
HTR2A P28223 4/20 0.31
HTR2C P28335 1/20 0.30
TAAR1 Q96RJ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28110649 0.77 HTR2A (0.32) HTR2AHTR2CTAAR1
SCHEMBL232462 0.73 CA2 (0.48) CA2CA4CA1CA6
SCHEMBL3393870 0.67 CA2 (0.46) CA2CA4CA1CA6
SCHEMBL5112438 0.65 CA2 (0.45) CA2CA4CA1CA6
SCHEMBL231210 0.65 CA2 (0.48) CA2CA4CA1CA6
SCHEMBL27743260 0.64 ALDH1A1 (0.34)
SCHEMBL3390514 0.64 CA2 (0.39) CA2CA4CA1CA6
SCHEMBL1192886 0.64 CA2 (0.43) CA2CA4CA1CA6
SCHEMBL3392782 0.64 CA2 (0.43) CA2CA4CA1CA6
SCHEMBL3394646 0.64 CA2 (0.43) CA2CA4CA1CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106132954-A 1,3 benzodioxole derivant 第三共株式会社 2016-11-16 CN disclosed