Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PARL | Q9H300 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28112314 | 0.87 | PKM (0.49) | PKMHTR6GRM4PARLHTT | |
| SCHEMBL23364667 | 0.83 | PKM (0.55) | PKMHTR6GAAPARLHTT | |
| SCHEMBL28196353 | 0.75 | PKM (0.42) | PKMHTR6GRM4GAAHTT | |
| SCHEMBL28195659 | 0.75 | GRM4 (0.43) | PKMHTR6GRM4HTTLMNA | |
| SCHEMBL27328752 | 0.74 | CA2 (0.36) | GRM4KDM4E | |
| SCHEMBL28053766 | 0.74 | PKM (0.57) | PKMHTR6CYP2D6CYP2C19PARL | |
| SCHEMBL2182451 | 0.73 | GRM4 (0.48) | HTR6GRM4GAAALDH1A1MEN1 | |
| SCHEMBL4614396 | 0.73 | PKM (0.56) | PKMHTR6GRM4CYP2D6CYP2C19 | |
| SCHEMBL12569759 | 0.73 | PKM (0.60) | PKMHTR6GRM4GAAPARL | |
| SCHEMBL1647468 | 0.73 | PKM (0.56) | PKMHTR6CYP2D6CYP2C19PARL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061943-B | It can be used as the bicyclic pyrrole derivatives of the agonist of GPR120 | 詹森药业有限公司 | 2019-11-05 | — | — | CN | disclosed |
| CN-106061943-A | Bicyclic pyrrole derivatives useful as agonists of GPR120 | 詹森药业有限公司 | 2016-10-26 | — | — | CN | disclosed |