Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 10/20 | 0.37 |
| ▸ | CDK2 | P24941 | 10/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 10/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16266936 | 0.79 | ALDH1A1 (0.39) | CCNE1CDK2CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL8833248 | 0.73 | CCNE1 (0.36) | CCNE1CDK2CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL25801701 | 0.73 | SMYD3 (0.40) | SMYD3SMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL31595821 | 0.72 | GSK3B (0.37) | GAA | |
| SCHEMBL24572410 | 0.69 | CCNE1 (0.49) | CCNE1CDK2CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL8833517 | 0.68 | CDK2 (0.33) | CCNE1CDK2CDK5CDK5R1 | |
| SCHEMBL24572407 | 0.68 | CCNE1 (0.45) | CCNE1CDK2CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL8833766 | 0.67 | CCNE1 (0.35) | CCNE1CDK2CDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL11937013 | 0.67 | MAPT (0.37) | — | |
| SCHEMBL8833251 | 0.66 | SMN1; SMN2 (0.35) | CCNE1CDK2CDK5CDK5R1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106068265-A | Dihydropyridone MGAT2 inhibitors for the treatment of metabolic disorders | 百时美施贵宝公司 | 2016-11-02 | — | — | CN | disclosed |