Hydrogen Sulfide

Hydrogen Sulfide

SCHEMBL28113024

CCCCCCCC(=O)NC(CC(=O)O)C(=O)NCC(=O)O.S

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 4/20 0.57
FAAH O00519 4/20 0.54
NOD1 Q9Y239 2/20 0.51
PLA2G2C Q5R387 1/20 0.51
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
PLA2G2A P14555 1/20 0.49
MAPK1 P28482 1/20 0.49
LPAR3 Q9UBY5 4/20 0.48
PLA2G10 O15496 2/20 0.48
LPAR1 Q92633 2/20 0.47
SLC6A5 Q9Y345 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27949922 0.99 EPHX2 (0.58) EPHX2FAAHNOD1PLA2G2CMEN1
SCHEMBL19160474 0.93 EPHX2 (0.51) EPHX2FAAHNOD1PLA2G2CMEN1
SCHEMBL27935271 0.89 NOD1 (0.58) FAAHNOD1PLA2G2CMEN1KMT2A
SCHEMBL6809578 0.89 NOD1 (0.58) FAAHNOD1PLA2G2CMEN1KMT2A
SCHEMBL17749138 0.88 EPHX2 (0.60) EPHX2FAAHNOD1PLA2G2CMEN1
SCHEMBL21277590 0.88 EPHX2 (0.60) EPHX2FAAHNOD1PLA2G2CMEN1
SCHEMBL12431172 0.87 EPHX2 (0.65) EPHX2NOD1PLA2G2CLPAR3PLA2G10
SCHEMBL2311133 0.87 EPHX2 (0.65) EPHX2NOD1PLA2G2CLPAR3PLA2G10
SCHEMBL10825260 0.87 EPHX2 (0.65) EPHX2NOD1PLA2G2CLPAR3PLA2G10
SCHEMBL26803330 0.85 EPHX2 (0.46) EPHX2FAAHNOD1PLA2G2CMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103561770-B Succinoyl compounds and their use for treating ischemic injury 艾雪米克斯公司 2016-11-09 CN disclosed