SCHEMBL28113260

SCHEMBL28113260

CC(C)(C)OC(=O)CC(Cc1ccccc1)NC(=O)OC(C)(C)C

nearest known ligand 0.68

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.68
APP P05067 4/20 0.56
CTSS P25774 3/20 0.55
CTSK P43235 2/20 0.55
CTSL P07711 1/20 0.55
CTSB P07858 1/20 0.55
ACE P12821 1/20 0.53
KLK5 Q9Y337 2/20 0.52
SYK P43405 1/20 0.51
ABCB1 P08183 1/20 0.51
CYP3A4 P08684 4/20 0.49
SCN9A Q15858 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28113259 1.00 ATM (0.68) ATMAPPCTSSCTSKCTSL
SCHEMBL7239876 0.93 ATM (0.67) ATMAPPCTSSCTSKCTSL
SCHEMBL6896458 0.93 ATM (0.67) ATMAPPCTSSCTSKCTSL
SCHEMBL13770955 0.93 ATM (0.67) ATMAPPCTSSCTSKCTSL
SCHEMBL1912659 0.92 CTSS (0.60) ATMAPPCTSSCTSKCTSL
SCHEMBL1912579 0.92 CTSS (0.60) ATMAPPCTSSCTSKCTSL
SCHEMBL489489 0.90 ATM (0.70) ATMAPPCTSSCTSKCTSL
SCHEMBL1519945 0.90 ATM (0.70) ATMAPPCTSSCTSKCTSL
SCHEMBL489490 0.90 ATM (0.70) ATMAPPCTSSCTSKCTSL
SCHEMBL15928906 0.90 ATM (0.62) ATMAPPCTSSCTSKCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106163509-A Beta-substituted beta-amino acids and analogs as chemotherapeutic agents 夸德里加生物科学公司 2016-11-23 CN disclosed