Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 13/20 | 0.55 |
| ▸ | PI4KB | Q9UBF8 | 13/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.54 |
| ▸ | PIP5K1C | O60331 | 5/20 | 0.54 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29646253 | 0.79 | PIK3CA (0.82) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL5532470 | 0.79 | PIK3CA (0.82) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL19031537 | 0.75 | ALKBH5 (0.62) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL16296381 | 0.73 | PIK3CA (0.77) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL8773471 | 0.71 | PIK3CA (1.00) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL27034701 | 0.71 | PI4KA (0.60) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL31404204 | 0.71 | PI4KA (0.60) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL25303570 | 0.70 | MAPT (0.74) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL9722748 | 0.70 | PIK3CA (0.73) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL31114470 | 0.70 | PIK3CA (0.73) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104024253-B | Heterocyclic amines as PI3K inhibitors | INCYTE HOLDINGS CORP. (US) | 2016-11-30 | — | — | CN | disclosed |