Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28114035 | 0.82 | PPARG (0.39) | PPARGPPARADPP4HSP90AB1HMGCR | |
| SCHEMBL28113489 | 0.80 | LMNA (0.39) | PPARGPPARADPP4HMGCRKDM4E | |
| SCHEMBL27980024 | 0.73 | HMGCR (0.47) | PPARGPPARADPP4HSP90AB1HMGCR | |
| SCHEMBL28693860 | 0.72 | HSP90AB1 (0.43) | PPARGPPARAHSP90AB1HMGCRKDM4E | |
| SCHEMBL27712795 | 0.68 | HSP90AB1 (0.47) | PPARGPPARAHSP90AB1HMGCRKDM4E | |
| SCHEMBL11537689 | 0.68 | AKR1C4 (0.60) | HSP90AB1HMGCRKDM4EMAPTHSD17B10 | |
| SCHEMBL28113527 | 0.68 | HMGCR (0.56) | PPARGPPARAHSP90AB1HMGCRKDM4E | |
| SCHEMBL9929857 | 0.67 | KDM4E (0.41) | PPARGPPARAHSP90AB1HMGCRKDM4E | |
| SCHEMBL9559940 | 0.66 | CYP3A4 (0.41) | HSP90AB1HMGCRKDM4ECYP3A4MEN1 | |
| SCHEMBL15364117 | 0.66 | HMGCR (0.55) | HSP90AB1HMGCRHSD17B10TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104024253-B | Heterocyclic amines as PI3K inhibitors | INCYTE HOLDINGS CORP. (US) | 2016-11-30 | — | — | CN | disclosed |