SCHEMBL28114069

SCHEMBL28114069

FC(F)(F)c1c[nH]nc1I

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CACNA1H O95180 1/20 0.32
NOTUM Q6P988 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21719642 0.76
SCHEMBL2528825 0.73
SCHEMBL31532399 0.71 NOTUM (0.30) NOTUM
SCHEMBL2198261 0.71 HSD11B1 (0.31) NOTUM
SCHEMBL20734528 0.68
SCHEMBL22616075 0.67 NOTUM (0.33) NOTUM
SCHEMBL31416457 0.67 KDM4E (0.33)
SCHEMBL27309533 0.66
SCHEMBL22616194 0.64 F10 (0.33) NOTUM
SCHEMBL31010340 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104114555-B Pyrazolopyrimidine derivatives, process for their preparation and their therapeutic use 赛诺菲 2017-09-01 CN disclosed
CN-106317056-A Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof 赛诺菲 2017-01-11 CN disclosed