Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 2/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.52 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.47 |
| ▸ | ANPEP | P15144 | 2/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | ACP3 | P15309 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15551372 | 1.00 | S1PR2 (0.52) | S1PR2S1PR4S1PR1S1PR3LTB4R | |
| SCHEMBL15549760 | 0.99 | S1PR2 (0.55) | S1PR2S1PR4S1PR1S1PR3LTB4R | |
| SCHEMBL17475099 | 0.95 | ANPEP (0.47) | S1PR2S1PR4S1PR1S1PR3ANPEP | |
| SCHEMBL15548807 | 0.95 | ANPEP (0.47) | S1PR2S1PR4S1PR1S1PR3ANPEP | |
| SCHEMBL17475095 | 0.95 | ANPEP (0.47) | S1PR2S1PR4S1PR1S1PR3ANPEP | |
| SCHEMBL28115038 | 0.89 | TSHR (0.55) | ANPEPERAP1ERAP2ACP3TSHR | |
| SCHEMBL15550825 | 0.89 | TSHR (0.55) | ANPEPERAP1ERAP2ACP3TSHR | |
| SCHEMBL28490132 | 0.85 | LTB4R (0.44) | S1PR2S1PR4S1PR1S1PR3LTB4R | |
| SCHEMBL15587064 | 0.85 | LTB4R (0.44) | S1PR2S1PR4S1PR1S1PR3LTB4R | |
| SCHEMBL17487074 | 0.84 | SMN1; SMN2 (0.46) | LTB4RTSHRHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107802623-A | For the bone related disease of EP4 mediations and the difluoro lactam composition of illness | 开曼化学股份有限公司 | 2018-03-16 | — | — | CN | disclosed |
| CN-104640542-B | Difluorolactam compositions for EP 4-mediated bone-related diseases and disorders | 开曼化学股份有限公司 | 2017-09-22 | — | — | CN | disclosed |
| CN-106748951-A | As the difluoro lactam compound of the EP4 receptor selective agonists used in the disease and symptom that treatment EP4 is mediated | 开曼化学股份有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-104583201-B | Difluorolactam compounds as EP4 receptor selective agonists for use in the treatment of EP4 mediated diseases and conditions | 开曼化学股份有限公司 | 2016-12-14 | — | — | CN | disclosed |