Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ERAP1 | Q9NZ08 | 4/20 | 0.54 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.54 |
| ▸ | ANPEP | P15144 | 2/20 | 0.54 |
| ▸ | ACP3 | P15309 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | IL1RN | P18510 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15550825 | 1.00 | TSHR (0.55) | TSHRERAP1ERAP2ANPEPACP3 | |
| SCHEMBL17475099 | 0.91 | ANPEP (0.47) | TSHRERAP1ERAP2ANPEPACP3 | |
| SCHEMBL15548807 | 0.91 | ANPEP (0.47) | TSHRERAP1ERAP2ANPEPACP3 | |
| SCHEMBL17475095 | 0.91 | ANPEP (0.47) | TSHRERAP1ERAP2ANPEPACP3 | |
| SCHEMBL28114912 | 0.89 | S1PR2 (0.52) | TSHRERAP1ERAP2ANPEPACP3 | |
| SCHEMBL15551372 | 0.89 | S1PR2 (0.52) | TSHRERAP1ERAP2ANPEPACP3 | |
| SCHEMBL15549760 | 0.88 | S1PR2 (0.55) | ERAP1ERAP2ANPEPACP3 | |
| SCHEMBL9041162 | 0.83 | LAP3 (0.51) | TSHRANPEPACP3KMT2AMEN1 | |
| SCHEMBL28115263 | 0.83 | LAP3 (0.51) | TSHRANPEPACP3KMT2AMEN1 | |
| SCHEMBL15586998 | 0.83 | TSHR (0.51) | TSHRERAP1ERAP2ANPEPACP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107802623-A | For the bone related disease of EP4 mediations and the difluoro lactam composition of illness | 开曼化学股份有限公司 | 2018-03-16 | — | — | CN | disclosed |
| CN-104640542-B | Difluorolactam compositions for EP 4-mediated bone-related diseases and disorders | 开曼化学股份有限公司 | 2017-09-22 | — | — | CN | disclosed |
| CN-106748951-A | As the difluoro lactam compound of the EP4 receptor selective agonists used in the disease and symptom that treatment EP4 is mediated | 开曼化学股份有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-104583201-B | Difluorolactam compounds as EP4 receptor selective agonists for use in the treatment of EP4 mediated diseases and conditions | 开曼化学股份有限公司 | 2016-12-14 | — | — | CN | disclosed |