Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | IDO1 | P14902 | 12/20 | 0.57 |
| ▸ | SLC11A2 | P49281 | 2/20 | 0.55 |
| ▸ | NOS1 | P29475 | 2/20 | 0.54 |
| ▸ | NOS3 | P29474 | 1/20 | 0.53 |
| ▸ | NOS2 | P35228 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2813631 | 0.98 | LMNA (0.62) | LMNAIDO1SLC11A2NOS1NOS3 | |
| SCHEMBL13067782 | 0.91 | LMNA (0.56) | LMNAIDO1SLC11A2NOS1NOS3 | |
| SCHEMBL17726956 | 0.87 | LMNA (0.56) | LMNAIDO1SLC11A2NOS1NOS3 | |
| Hydrochloric Acid SCHEMBL22282522 | 0.85 | LMNA (0.58) | LMNAIDO1SLC11A2NOS1NOS3 | |
| SCHEMBL860205 | 0.85 | LMNA (0.50) | LMNAIDO1SLC11A2NOS1NOS3 | |
| Hydrochloric Acid SCHEMBL11356922 | 0.84 | LMNA (0.57) | LMNAIDO1SLC11A2NOS1NOS3 | |
| Hydrochloric Acid SCHEMBL860105 | 0.84 | LMNA (0.53) | LMNAIDO1SLC11A2NOS1NOS3 | |
| Bromide SCHEMBL23391499 | 0.79 | LMNA (0.93) | LMNAIDO1SLC11A2NOS1NOS3 | |
| Bromide SCHEMBL30145206 | 0.79 | LMNA (0.93) | LMNAIDO1SLC11A2NOS1NOS3 | |
| SCHEMBL10118167 | 0.78 | LMNA (0.43) | LMNAIDO1SLC11A2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240713-A1 | AROMATIC AND HETEROAROMATIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2010-09-23 | — | — | US | disclosed |
| EP-2068855-A2 | AROMATIC AND HETEROAROMATIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008151288-A2 | AROMATIC AND HETEROAROMATIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240713-A1 | AROMATIC AND HETEROAROMATIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | SLC40A1, PAH, FECH | LMNA 3426/4885IDO1 131/4885SLC11A2 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.