Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | PRKACA | P17612 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | MARK3 | P27448 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.38 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660606 | 0.78 | MET (0.58) | METKITKDR | |
| SCHEMBL27911887 | 0.73 | EGLN2 (0.34) | ALOX5APFEN1KIT | |
| SCHEMBL3119349 | 0.70 | MAP2K3 (0.39) | CDC7CDK8MKNK2MET | |
| SCHEMBL712310 | 0.69 | TSHR (0.48) | MAPK1KIT | |
| SCHEMBL17183536 | 0.69 | PARP10 (0.46) | CDK8CDK9METAURKA | |
| SCHEMBL1980078 | 0.68 | MAP4K4 (0.39) | PLK4MAPK13DAPK3CDK1PRKACA | |
| SCHEMBL28345330 | 0.68 | KMO (0.45) | PLK4MAPK13DAPK3CHEK2CDK1 | |
| SCHEMBL25262586 | 0.67 | KIT (0.39) | CDK9ALOX5APFEN1KIT | |
| SCHEMBL30166671 | 0.67 | MAPK9 (0.44) | PLK4MAPK13DAPK3CHEK2CDK1 | |
| SCHEMBL30363113 | 0.67 | KDM4C (0.42) | PLK4MAPK13DAPK3CDK1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102977125-B | One class 2,7 7-naphthyridine derivatives and its preparation method and application | JIANGSU SIMCERE PHARMACEUTICAL CO., LTD. (CN) | 2016-12-14 | — | — | CN | disclosed |