Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347296 | 0.89 | TDP1 (0.50) | USP2SLCO1B1TDP1PDE4ALMNA | |
| SCHEMBL349281 | 0.89 | TDP1 (0.50) | USP2SLCO1B1TDP1PDE4ALMNA | |
| SCHEMBL28404010 | 0.82 | LMNA (0.43) | USP2SLCO1B1TDP1PDE4ALMNA | |
| Mannitol SCHEMBL27352819 | 0.80 | USP2 (0.60) | USP2SLCO1B1TDP1PDE4ALMNA | |
| Mannitol SCHEMBL1287879 | 0.80 | USP2 (0.60) | USP2SLCO1B1TDP1PDE4ALMNA | |
| SCHEMBL9138710 | 0.79 | TDP1 (0.46) | USP2SLCO1B1TDP1PDE4ALMNA | |
| SCHEMBL1287880 | 0.79 | TDP1 (0.46) | USP2SLCO1B1TDP1PDE4ALMNA | |
| SCHEMBL27740481 | 0.76 | TDP1 (0.52) | USP2SLCO1B1TDP1PDE4ALMNA | |
| SCHEMBL1856422 | 0.76 | TDP1 (0.43) | USP2SLCO1B1TDP1PDE4ALMNA | |
| Adonitol SCHEMBL27529790 | 0.75 | USP2 (0.54) | USP2SLCO1B1TDP1PDE4ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106236711-A | Phloretin liposome and preparation method thereof | 广东工业大学 | 2016-12-21 | — | — | CN | disclosed |