Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenylglycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM6 | O15303 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylglycine SCHEMBL30559595 | 0.93 | CYP2D6 (0.56) | CYP2D6SRCLMNAMAPK1HSD17B10 | |
| Phenylglycine SCHEMBL27801493 | 0.93 | CYP2D6 (0.56) | CYP2D6SRCLMNAMAPK1HSD17B10 | |
| Phenylglycine SCHEMBL71958 | 0.93 | CYP2D6 (0.56) | CYP2D6SRCLMNAMAPK1HSD17B10 | |
| Phenylglycine SCHEMBL31402004 | 0.93 | CYP2D6 (0.56) | CYP2D6SRCLMNAMAPK1HSD17B10 | |
| Phenylglycine SCHEMBL11576917 | 0.93 | CYP2D6 (0.56) | CYP2D6SRCLMNAMAPK1HSD17B10 | |
| Phenylglycine SCHEMBL159420 | 0.93 | CYP2D6 (0.56) | CYP2D6SRCLMNAMAPK1HSD17B10 | |
| Phenylglycine SCHEMBL157180 | 0.93 | CYP2D6 (0.56) | CYP2D6SRCLMNAMAPK1HSD17B10 | |
| Phenylglycine SCHEMBL30631311 | 0.91 | CYP2D6 (0.50) | CYP2D6SRCLMNAMAPK1HSD17B10 | |
| Phenylglycine SCHEMBL6718142 | 0.91 | CYP2D6 (0.54) | CYP2D6SRCLMNAMAPK1HSD17B10 | |
| Phenylglycine SCHEMBL540378 | 0.91 | CYP2D6 (0.54) | CYP2D6SRCLMNAMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106278925-B | A kind of preparation method of Antirheumatic Drug Actarit | 平光制药股份有限公司 | 2019-01-25 | — | — | CN | disclosed |
| CN-106278925-A | A kind of preparation method of Antirheumatic Drug Actarit | 平光制药股份有限公司 | 2017-01-04 | — | — | CN | disclosed |