Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.60 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.60 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.53 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KDM5C | P41229 | 2/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28325526 | 0.93 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL28124268 | 0.84 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL18916897 | 0.82 | — | — | |
| Adipic Acid SCHEMBL28127756 | 0.81 | LMNA (0.65) | LMNAOR51E2SLC22A6TSHRNFKB1 | |
| Succinic Acid SCHEMBL285597 | 0.79 | LMNA (0.69) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL27549020 | 0.78 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL11666801 | 0.78 | — | — | |
| Sulfuric Acid SCHEMBL4535186 | 0.78 | CA1 (0.46) | APEX1TSHRCA1CA2POLB | |
| Succinic Acid SCHEMBL4269130 | 0.78 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL1331200 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102438584-B | The method processing damaged hair | 罗地亚管理公司 | 2016-12-21 | — | — | CN | disclosed |