Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 1.00 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 1.00 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.67 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.64 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | KDM5C | P41229 | 2/20 | 0.56 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL8992010 | 1.00 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL3799615 | 1.00 | — | — | |
| Succinic Acid SCHEMBL1331252 | 1.00 | — | — | |
| Succinic Acid SCHEMBL829 | 1.00 | — | — | |
| Succinic Acid SCHEMBL4269135 | 1.00 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL24696 | 1.00 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL29808469 | 1.00 | — | — | |
| Succinic Acid SCHEMBL1331200 | 1.00 | — | — | |
| Succinic Acid SCHEMBL21867134 | 1.00 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL28176099 | 1.00 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10632051-B2 | Hair bleaching agent and method for gentle oxidative lightening of hair | HENKEL AG & CO. KGAA (DE) | 2020-04-28 | — | — | US | claimed |
| CN-105492476-B | Polyorganosiloxane-containing graft copolymer, thermoplastic resin composition, and molded article | 三菱化学株式会社 | 2020-08-14 | — | — | CN | disclosed |
| CN-111440275-A | Polyorganosiloxane-containing graft copolymer, thermoplastic resin composition, and molded article | 三菱化学株式会社 | 2020-07-24 | — | — | CN | disclosed |
| CN-109206313-A | The method that succinate anaerobic fermented liquid prepares succinic acid | 中国石化扬子石油化工有限公司 | 2019-01-15 | — | — | CN | disclosed |
| EP-1625626-B1 | PHOTODIODE PASSIVATION TECHNIQUE | RAYTHEON CO (US) | 2009-02-25 | — | — | EP | disclosed |
| CN-1294206-C | Polyamide composition incorporating non-melt-processible fluoropolymer and method of making same | DU PONT (US) | 2007-01-10 | — | — | CN | disclosed |
| US-7030032-B2 | Photodiode passivation technique | RAYTHEON COMPANY (US) | 2006-04-18 | — | — | US | disclosed |
| EP-1625626-A1 | PHOTODIODE PASSIVATION TECHNIQUE | Raytheon Company (US) | 2006-02-15 | — | — | EP | disclosed |
| CN-1678686-A | Polyamide composition incorporating non-melt-processible fluoropolymer and method of making same | PONT LTD DU (US) | 2005-10-05 | — | — | CN | disclosed |
| WO-2004102682-A1 | PHOTODIODE PASSIVATION TECHNIQUE | RAYTHEON COMPANY (US) | 2004-11-25 | — | — | WO | disclosed |
| US-20040229469-A1 | Photodiode passivation technique | RAYTHEON COMPANY | 2004-11-18 | — | — | US | disclosed |
| EP-0249380-B1 | Shade enhancing agent | KAO CORP (JP) | 1993-11-03 | — | — | EP | disclosed |
| US-5126392-A | Color deepening with emulsion-polymerized resin and cationic protective colloid | KAO CORPORATION (JP) | 1992-06-30 | — | — | US | disclosed |
| EP-0249380-A2 | Shade enhancing agent | Kao Corporation (JP) | 1987-12-16 | — | — | EP | disclosed |
| US-4373043-A | Color deepening agent | KAO SOAP CO., LTD. (JP) | 1983-02-08 | — | — | US | disclosed |
| US-4373053-A | Color deepening agent | KAO SOAP CO., LTD. (JP) | 1983-02-08 | — | — | US | disclosed |
| US-3939138-A | HYDROPEROXIDE OF A ROSIN ACID DERIVATIVE | NIPPON ZEON CO., LTD. (JA) | 1976-02-17 | — | — | US | disclosed |