Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19654571 | 0.89 | HSD17B10 (0.67) | HSD17B10ALDH1A1HIF1AKMT2AMAPT | |
| SCHEMBL169304 | 0.89 | HSD17B10 (0.67) | HSD17B10ALDH1A1HIF1AKMT2AMAPT | |
| SCHEMBL29535654 | 0.89 | HSD17B10 (0.67) | HSD17B10ALDH1A1HIF1AKMT2AMAPT | |
| Ammonia Solution, Strong SCHEMBL28217171 | 0.88 | HSD17B10 (0.64) | HSD17B10ALDH1A1HIF1AKMT2AMAPT | |
| SCHEMBL9484826 | 0.86 | HSD17B10 (0.58) | HSD17B10ALDH1A1HIF1AKMT2AMAPT | |
| Alcohol SCHEMBL28147802 | 0.84 | HSD17B10 (0.78) | HSD17B10ALDH1A1KMT2AMAPTMAPK1 | |
| Alcohol SCHEMBL27914560 | 0.81 | ALDH1A1 (0.79) | HSD17B10ALDH1A1HIF1AKMT2AMAPT | |
| Alcohol SCHEMBL28841881 | 0.78 | CYP1A2 (0.59) | HSD17B10ALDH1A1KMT2AMAPTGAA | |
| Dinitrochlorobenzene SCHEMBL28015617 | 0.78 | HSD17B10 (0.56) | HSD17B10ALDH1A1KMT2AMAPK1MEN1 | |
| Alcohol SCHEMBL27929511 | 0.76 | ALDH1A1 (0.79) | ALDH1A1KMT2AMAPTHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104741148-B | Method for preparing 3-chlorine-4 fluoronitrobenzene hydrogenation catalyst | 浙江衢州万能达科技有限公司 | 2017-02-08 | — | — | CN | disclosed |