Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.55 |
| ▸ | CTSK | P43235 | 6/20 | 0.52 |
| ▸ | CTSS | P25774 | 5/20 | 0.52 |
| ▸ | CTSB | P07858 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGAV | P06756 | 1/20 | 0.45 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22674864 | 0.89 | CTSS (0.56) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL22117444 | 0.88 | CTSK (0.57) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL22117445 | 0.88 | CTSK (0.57) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL5966551 | 0.88 | CTSK (0.57) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL22117446 | 0.88 | CTSK (0.57) | ACECTSKCTSSCTSBCTSL | |
| SCHEMBL5966543 | 0.88 | CTSK (0.57) | ACECTSKCTSSCTSBCTSL | |
| Dl-Tryptophan SCHEMBL28131404 | 0.88 | ACE (0.60) | ACECTSKCTSSCTSL | |
| Arginine SCHEMBL28924040 | 0.85 | ACE (0.42) | ACECTSKCTSSCTSBCTSL | |
| Dl-Tryptophan SCHEMBL28130697 | 0.85 | ACE (0.57) | ACECTSKCTSSCTSL | |
| Lysine SCHEMBL29140134 | 0.85 | ACE (0.60) | ACECTSKCTSSCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106478771-A | A kind of synthetic method of amino acid neural tetrapeptide | 李世军 | 2017-03-08 | — | — | CN | claimed |
| CN-106279354-A | A kind of synthetic method of amino acid neural dipeptides | 温州医科大学 | 2017-01-04 | — | — | CN | claimed |
| CN-106478771-A | A kind of synthetic method of amino acid neural tetrapeptide | 李世军 | 2017-03-08 | — | — | CN | disclosed |
| CN-106478771-A | A kind of synthetic method of amino acid neural tetrapeptide | 李世军 | 2017-03-08 | — | — | CN | disclosed |
| CN-106279354-A | A kind of synthetic method of amino acid neural dipeptides | 温州医科大学 | 2017-01-04 | — | — | CN | disclosed |
| CN-106279354-A | A kind of synthetic method of amino acid neural dipeptides | 温州医科大学 | 2017-01-04 | — | — | CN | disclosed |