Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KDM5C | P41229 | 1/20 | 0.46 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL49856 | 0.84 | ALDH1A1 (0.62) | CTSDALDH1A1GAAKDM4EKDM5C | |
| SCHEMBL28219205 | 0.84 | ALDH1A1 (0.62) | CTSDALDH1A1GAAKDM4EKDM5C | |
| Acetone SCHEMBL22554792 | 0.82 | CTSD (0.59) | CTSDALDH1A1GAAKDM4EKDM5C | |
| Acetone SCHEMBL6392906 | 0.82 | CTSD (0.59) | CTSDALDH1A1GAAKDM4EKDM5C | |
| SCHEMBL4186692 | 0.82 | ALDH1A1 (0.67) | CTSDALDH1A1GAAKDM4EKDM5C | |
| SCHEMBL6636984 | 0.82 | ALDH1A1 (0.67) | CTSDALDH1A1GAAKDM4EKDM5C | |
| Ammonia Solution, Strong SCHEMBL15129241 | 0.82 | ALDH1A1 (0.60) | CTSDALDH1A1GAAKDM4EKDM5C | |
| Water SCHEMBL4942958 | 0.82 | ALDH1A1 (0.60) | CTSDALDH1A1GAAKDM4EKDM5C | |
| SCHEMBL4187314 | 0.82 | KDM4E (0.65) | CTSDALDH1A1GAAKDM4EKDM5C | |
| SCHEMBL9007204 | 0.82 | ALDH1A1 (0.60) | CTSDALDH1A1GAAKDM4EKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106334192-A | Sericin hydrogel, preparation method and application thereof | 华中科技大学同济医学院附属协和医院 | 2017-01-18 | — | — | CN | claimed |
| CN-106334192-A | Sericin hydrogel, preparation method and application thereof | 华中科技大学同济医学院附属协和医院 | 2017-01-18 | — | — | CN | disclosed |