Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMG1 | Q96Q15 | 4/20 | 0.70 |
| ▸ | PLK4 | O00444 | 5/20 | 0.68 |
| ▸ | OGA | O60502 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.53 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28085067 | 0.89 | PLK4 (0.68) | PLK4JAK2IGF1RAURKAAURKB | |
| SCHEMBL2376107 | 0.88 | SMG1 (0.56) | SMG1PLK4OGAJAK2LMNA | |
| SCHEMBL22860794 | 0.83 | POLB (0.61) | SMG1AURKACDK1CDK2ALDH1A1 | |
| SCHEMBL24426184 | 0.83 | JAK2 (0.81) | PLK4JAK2AURKAFLT3KDM4E | |
| SCHEMBL13648583 | 0.81 | JAK2 (0.75) | SMG1JAK2CDK1CDK2FLT3 | |
| SCHEMBL2374456 | 0.80 | PLK4 (0.60) | PLK4JAK2IGF1RAURKAAURKB | |
| SCHEMBL31681842 | 0.80 | PLK4 (0.60) | PLK4JAK2IGF1RAURKAAURKB | |
| SCHEMBL3811303 | 0.79 | OGA (0.59) | SMG1PLK4OGAJAK2LMNA | |
| SCHEMBL9678255 | 0.79 | OGA (0.59) | SMG1PLK4OGAJAK2FLT3 | |
| SCHEMBL7260518 | 0.78 | SMG1 (0.52) | SMG1PLK4OGAJAK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316963-B | Polymorphs of a morpholino phenylaminopyrimidine compound or salt thereof | 苏州泽璟生物制药股份有限公司 | 2021-06-08 | — | — | CN | disclosed |
| CN-106316963-B | Polymorphs of a morpholino phenylaminopyrimidine compound or salt thereof | 苏州泽璟生物制药股份有限公司 | 2021-06-08 | — | — | CN | disclosed |
| CN-106316963-B | Polymorphs of a morpholino phenylaminopyrimidine compound or salt thereof | 苏州泽璟生物制药股份有限公司 | 2021-06-08 | — | — | CN | disclosed |
| CN-106316963-A | Polymorphic substances of morpholinophenylaminopyrimidine compound or salts thereof | 苏州泽璟生物制药有限公司 | 2017-01-11 | — | — | CN | disclosed |
| CN-106316963-A | Polymorphic substances of morpholinophenylaminopyrimidine compound or salts thereof | 苏州泽璟生物制药有限公司 | 2017-01-11 | — | — | CN | disclosed |