Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMG1 | Q96Q15 | 8/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | MTOR | P42345 | 3/20 | 0.50 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.50 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | OGA | O60502 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17113389 | 0.79 | SYK (0.52) | SYKIMPDH2ABL1BCRPRKCQ | |
| SCHEMBL4476385 | 0.79 | SYK (0.52) | SYKCAMK2DABL1BCRPRKCQ | |
| SCHEMBL28118781 | 0.78 | SMG1 (0.70) | SMG1CDK1CDK2JAK2PLK4 | |
| SCHEMBL18627934 | 0.75 | SYK (0.56) | SMG1CDK1CDK2SYKMTOR | |
| SCHEMBL17113289 | 0.75 | SYK (0.67) | SMG1CDK1CDK2SYKMTOR | |
| SCHEMBL18627925 | 0.75 | SYK (0.46) | SMG1CDK1CDK2SYKMTOR | |
| SCHEMBL28794175 | 0.73 | MAP4K4 (0.55) | IMPDH2JAK3 | |
| SCHEMBL28085067 | 0.73 | PLK4 (0.68) | CDK2JAK2PLK4 | |
| SCHEMBL15022350 | 0.73 | ALK (0.73) | — | |
| SCHEMBL18627912 | 0.73 | SMG1 (0.44) | SMG1CDK1CDK2SYKMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003040141-A1 | OXAZOLYL-PHENYL-2,4-DIAMINO-PYRIMIDINE COMPOUNDS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-05-15 | — | — | WO | claimed |
| WO-2003040141-A1 | OXAZOLYL-PHENYL-2,4-DIAMINO-PYRIMIDINE COMPOUNDS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-05-15 | — | — | WO | disclosed |