SCHEMBL28118863

SCHEMBL28118863

O=C(c1nc2cc([N+](=O)[O-])c([N+](=O)[O-])cc2[nH]1)c1nc2cc([N+](=O)[O-])c([N+](=O)[O-])cc2[nH]1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.56
NPC1 O15118 2/20 0.54
RAB9A P51151 2/20 0.54
MAPT P10636 3/20 0.46
LMNA P02545 2/20 0.46
GRIN2D O15399 1/20 0.46
GRIN3B O60391 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
HPGD P15428 1/20 0.46
TSHR P16473 1/20 0.46
GRIK1 P39086 1/20 0.46
GRIA1 P42261 1/20 0.46
GRIA2 P42262 1/20 0.46
GRIA3 P42263 1/20 0.46
GRIA4 P48058 1/20 0.46
BLM P54132 1/20 0.46
GRIN1 Q05586 1/20 0.46
GRIN2A Q12879 1/20 0.46
GRIK2 Q13002 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27460746 0.88 NPC1 (0.49) GAANPC1RAB9AMAPTTSHR
SCHEMBL27937212 0.88 NPC1 (0.49) GAANPC1RAB9AMAPTLMNA
SCHEMBL29110051 0.88 NPC1 (0.49) GAANPC1RAB9AMAPTLMNA
SCHEMBL27546377 0.88 MAPT (0.54) GAANPC1RAB9AMAPTLMNA
SCHEMBL27447055 0.78 ALDH1A1 (0.63) NPC1RAB9AMAPTLMNACYP1A2
SCHEMBL27354737 0.78 ALDH1A1 (0.54) NPC1RAB9AMAPTLMNACYP1A2
SCHEMBL5008296 0.77 GAA (0.66) GAANPC1RAB9AMAPTLMNA
SCHEMBL4364726 0.76 GAA (0.59) GAANPC1RAB9AMAPTLMNA
SCHEMBL28016935 0.72 FABP6 (0.53) NPC1RAB9AMAPTLMNACYP1A2
SCHEMBL11745692 0.71 CHEK2 (0.60) NPC1RAB9AMAPTHPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106336381-B The preparation method of the dinitro benzimidazolone of one pot process 5,6 东营市天正化工有限公司 2017-10-13 CN disclosed
CN-106336381-A Preparation method for one-pot synthesis of 5,6-dinitrobenzimidazolone 东营市天正化工有限公司 2017-01-18 CN disclosed