Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.49 |
| ▸ | KDM4A | O75164 | 7/20 | 0.49 |
| ▸ | KDM5C | P41229 | 6/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.49 |
| ▸ | KDM3A | Q9Y4C1 | 4/20 | 0.49 |
| ▸ | KDM5A | P29375 | 4/20 | 0.49 |
| ▸ | KDM6B | O15054 | 3/20 | 0.49 |
| ▸ | TET3 | O43151 | 1/20 | 0.49 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ASPH | Q12797 | 1/20 | 0.49 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.49 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.49 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.49 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.49 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30505322 | 1.00 | PROKR1 (0.49) | PROKR1KDM4CKDM4AKDM5CKDM5B | |
| SCHEMBL30228066 | 0.85 | PROKR1 (0.48) | PROKR1KDM4CKDM5CKDM5BKDM5A | |
| SCHEMBL27244621 | 0.85 | PROKR1 (0.48) | PROKR1KDM5CKDM5BKDM5AALDH1A1 | |
| SCHEMBL11340185 | 0.82 | KDM4E (0.55) | PROKR1KDM4CKDM4AKDM5CKDM5B | |
| SCHEMBL3350177 | 0.81 | KDM4C (0.44) | KDM4CKDM4AKDM5CKDM5BKDM4E | |
| Hydrochloric Acid SCHEMBL15973575 | 0.81 | KDM4E (0.53) | PROKR1KDM4CKDM4AKDM5CKDM5B | |
| SCHEMBL24473745 | 0.77 | KDM5B (0.50) | PROKR1KDM4CKDM4AKDM5CKDM5B | |
| SCHEMBL6398480 | 0.75 | KDM4C (0.49) | PROKR1KDM4CKDM4AKDM5CKDM5B | |
| SCHEMBL3352698 | 0.75 | HCAR3 (0.60) | KDM4CKDM4AKDM5CKDM5BKDM4E | |
| SCHEMBL2816763 | 0.75 | KDM5B (0.41) | KDM4CKDM4AKDM5CKDM5BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230286968-A1 | ARYLOXAZOLO SPIRAL RING DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2023-09-14 | — | — | US | disclosed |
| US-20230286968-A1 | ARYLOXAZOLO SPIRAL RING DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2023-09-14 | — | — | US | disclosed |
| CN-116457352-A | Aryloxazolo spiro derivatives for the treatment and prophylaxis of hepatitis b virus infection | 豪夫迈·罗氏有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022112140-A1 | ARYLOXAZOLO SPIRAL RING DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2022-06-02 | — | — | WO | disclosed |
| WO-2010117662-A1 | MODULATORS OF S1P AND METHODS OF MAKING AND USING | EXELIXIS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010117662-A1 | MODULATORS OF S1P AND METHODS OF MAKING AND USING | EXELIXIS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| US-20100249071-A1 | Modulators of S1P and Methods of Making And Using | EXELIXIS, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249071-A1 | Modulators of S1P and Methods of Making And Using | EXELIXIS, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249071-A1 | Modulators of S1P and Methods of Making And Using | EXELIXIS, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249071-A1 | Modulators of S1P and Methods of Making And Using | S1PR5, S1PR1, S1PR2 | PROKR1 951/4885KDM4C 2232/4885KDM4A 2119/4885 |
| US-20230286968-A1 | ARYLOXAZOLO SPIRAL RING DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HAVCR2, CYP4B1, CYP1B1 | PROKR1 2146/4885KDM4C 1182/4885KDM4A 817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.