Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | PKM | P14618 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9587190 | 0.85 | KDM4E (0.69) | KDM4EPKMALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL496662 | 0.84 | KDM4E (0.72) | KDM4EPKMALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5530041 | 0.77 | ALDH1A1 (0.61) | KDM4EALDH1A1L3MBTL1HPGDHSD17B10 | |
| SCHEMBL9587412 | 0.76 | KDM4E (0.51) | KDM4EPKMALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL495789 | 0.75 | KDM4E (0.72) | KDM4EPKMALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9586961 | 0.74 | KDM4E (1.00) | KDM4EPKMALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL28122725 | 0.74 | KDM4E (0.58) | KDM4EPKMALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL11751223 | 0.73 | ALOX5 (0.58) | KDM4EALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL11751772 | 0.73 | ALOX5 (0.58) | KDM4EALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL18003674 | 0.72 | KDM4E (0.57) | KDM4EPKMALDH1A1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106414434-A | Isothiazole derivatives as gpr120 agonists for the treatment of type ii diabetes | 詹森药业有限公司 | 2017-02-15 | — | — | CN | disclosed |