Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28124791 | 0.85 | GPR119 (0.49) | USP30USP2SMN1; SMN2GPR119MEN1 | |
| SCHEMBL21641106 | 0.82 | DDB1 (0.49) | NR1H2DDB1CRBNUSP30USP2 | |
| SCHEMBL14697592 | 0.81 | NR1H2 (0.50) | NR1H2DDB1CRBNUSP30USP2 | |
| SCHEMBL3563885 | 0.80 | DDB1 (0.52) | NR1H2DDB1CRBNUSP30USP2 | |
| SCHEMBL24161826 | 0.79 | NR1H2 (0.51) | NR1H2DDB1CRBNUSP30USP2 | |
| SCHEMBL24027370 | 0.78 | NR1H2 (0.48) | NR1H2DDB1CRBNUSP30USP2 | |
| SCHEMBL28124192 | 0.77 | NR1H2 (0.42) | NR1H2DDB1CRBNUSP30USP2 | |
| SCHEMBL21966137 | 0.77 | DDB1 (0.50) | NR1H2DDB1CRBNUSP30USP2 | |
| SCHEMBL19441802 | 0.77 | DDB1 (0.50) | NR1H2DDB1CRBNUSP30USP2 | |
| SCHEMBL22989452 | 0.76 | NR1H2 (0.49) | NR1H2DDB1CRBNUSP30USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106459034-B | Carbostyril derivative as fibroblast growth factor acceptor inhibitor | 普林斯匹亚生物制药公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-106459034-A | Quinolone derivatives as fibroblast growth factor receptor inhibitors | 普林斯匹亚生物制药公司 | 2017-02-22 | — | — | CN | disclosed |