SCHEMBL2812455

SCHEMBL2812455

COC(=O)C(=CSc1ccccc1)Sc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.38
MAPT P10636 4/20 0.38
NPSR1 Q6W5P4 4/20 0.38
ALDH1A1 P00352 3/20 0.38
PLIN1 O60240 1/20 0.38
HPGD P15428 1/20 0.38
HTT P42858 1/20 0.38
PLIN5 Q00G26 1/20 0.38
ABHD5 Q8WTS1 1/20 0.38
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35
KMT2A Q03164 3/20 0.33
MEN1 O00255 2/20 0.33
KCNN4 O15554 1/20 0.33
NFKB1 P19838 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
PABPC1 P11940 1/20 0.33
EIF4H Q15056 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2812454 1.00 LMNA (0.38) LMNAMAPTNPSR1ALDH1A1PLIN1
SCHEMBL2815259 0.91 ALDH1A1 (0.37) LMNAMAPTALDH1A1HPGDHTT
SCHEMBL2815262 0.91 ALDH1A1 (0.37) LMNAMAPTALDH1A1HPGDHTT
SCHEMBL2812788 0.87 MAPT (0.38) LMNAMAPTNPSR1ALDH1A1PLIN1
SCHEMBL3041618 0.87 MAPT (0.38) LMNAMAPTNPSR1ALDH1A1PLIN1
SCHEMBL2812785 0.87 MAPT (0.38) LMNAMAPTNPSR1ALDH1A1PLIN1
SCHEMBL2812491 0.81 TSHR (0.37) LMNAMAPTNPSR1ALDH1A1HPGD
SCHEMBL2812489 0.81 TSHR (0.37) LMNAMAPTNPSR1ALDH1A1HPGD
SCHEMBL2812825 0.80 ALDH1A1 (0.43) LMNAMAPTNPSR1ALDH1A1PLIN1
SCHEMBL2812828 0.80 ALDH1A1 (0.43) LMNAMAPTNPSR1ALDH1A1PLIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8278473-B2 Alpha, beta-unsaturated imidate compound and pesticidal composition containing the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-02 US disclosed
US-8278473-B2 Alpha, beta-unsaturated imidate compound and pesticidal composition containing the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-02 US disclosed
US-8278473-B2 Alpha, beta-unsaturated imidate compound and pesticidal composition containing the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-02 US disclosed
US-20100240729-A1 ALPHA, BETA-UNSATURATED IMIDATE COMPOUND AND PESTICIDAL COMPOSITION CONTAINING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-09-23 US disclosed
US-20100240729-A1 ALPHA, BETA-UNSATURATED IMIDATE COMPOUND AND PESTICIDAL COMPOSITION CONTAINING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-09-23 US disclosed
US-20100240729-A1 ALPHA, BETA-UNSATURATED IMIDATE COMPOUND AND PESTICIDAL COMPOSITION CONTAINING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-09-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100240729-A1 ALPHA, BETA-UNSATURATED IMIDATE COMPOUND AND PESTICIDAL COMPOSITION CONTAINING THE SAME OXER1, CBR1, DEGS1 LMNA 2201/4885MAPT 4608/4885NPSR1 967/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.