Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28125976 | 0.83 | S1PR1 (0.36) | KDM4ETDP1MEN1KMT2A | |
| SCHEMBL16794015 | 0.79 | BTK (0.60) | BTKP2RX7 | |
| SCHEMBL28238065 | 0.76 | NR1H2 (0.42) | NR1H2GPR183DDR1 | |
| SCHEMBL28238068 | 0.74 | BTK (0.45) | BTK | |
| SCHEMBL24192812 | 0.73 | NR1H2 (0.47) | NR1H2GPR183DDR1KDM4E | |
| SCHEMBL18580987 | 0.71 | GPR183 (0.48) | NR1H2GPR183DDR1KDM4EKMT2A | |
| SCHEMBL2800197 | 0.71 | PDE3B (0.55) | NR1H2GPR183KDM4E | |
| SCHEMBL24566187 | 0.71 | NR1H2 (0.61) | NR1H2DDR1P2RX7KDM4ETDP1 | |
| SCHEMBL22462793 | 0.69 | USP30 (0.45) | NR1H2KDM4ETDP1 | |
| SCHEMBL30272631 | 0.69 | USP30 (0.45) | NR1H2KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109096274-A | It can be used for treating the aryl-linking compound of human tumor, neurology and amynologic disease | 比奥根MA公司 | 2018-12-28 | — | — | CN | disclosed |
| CN-108947913-A | It can be used for treating the aryl-linking compound of human tumor, neurology and amynologic disease | 比奥根MA公司 | 2018-12-07 | — | — | CN | disclosed |
| CN-106459002-B | Biaryl compounds useful in the treatment of human oncological, neurological and immunological diseases | 比奥根MA公司 | 2018-08-21 | — | — | CN | disclosed |
| CN-106459002-A | Biaryl compounds useful in the treatment of human oncological, neurological and immunological diseases | 比奥根MA公司 | 2017-02-22 | — | — | CN | disclosed |