Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NNMT | P40261 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | RAF1 | P04049 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28935930 | 0.77 | POLB (0.42) | POLBTDP1NNMTERN1CYP1A2 | |
| SCHEMBL29091456 | 0.77 | POLB (0.42) | POLBTDP1NNMTERN1CYP1A2 | |
| SCHEMBL586103 | 0.76 | NNMT (0.53) | POLBTDP1NNMTERN1CYP1A2 | |
| SCHEMBL323351 | 0.76 | POLB (0.55) | POLBTDP1NNMTERN1CYP1A2 | |
| SCHEMBL30619421 | 0.74 | POLB (0.40) | POLBTDP1NNMTERN1CYP1A2 | |
| SCHEMBL3099634 | 0.74 | NNMT (0.39) | POLBTDP1NNMTCYP1A2SIRT2 | |
| SCHEMBL13213488 | 0.74 | POLB (0.40) | POLBTDP1NNMTERN1CYP1A2 | |
| SCHEMBL15467080 | 0.74 | POLB (0.40) | POLBTDP1NNMTERN1CYP1A2 | |
| SCHEMBL30427669 | 0.74 | NNMT (0.43) | POLBTDP1NNMTERN1CYP1A2 | |
| SCHEMBL20613046 | 0.71 | KMT2A (0.45) | POLBTDP1NNMTERN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108164513-A | Substituted oxo pyridine derivative and its purposes in terms of cardiovascular disorder is treated | 拜耳制药股份公司 | 2018-06-15 | — | — | CN | disclosed |
| CN-105164122-B | Substituted oxopyridine derivatives and their use in the treatment of cardiovascular disorders | 拜耳制药股份公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-105849109-B | Substituted oxopyridine derivatives | 拜耳制药股份公司 | 2018-01-23 | — | — | CN | disclosed |
| CN-106687458-A | Substituted oxopyridine derivatives | 拜耳制药股份公司 | 2017-05-17 | — | — | CN | disclosed |