Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | QDPR | P09417 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19347097 | 0.80 | HTR2B (0.43) | HTR2BQDPRALDH1A1TDP1CNR1 | |
| SCHEMBL27748636 | 0.80 | PRMT5 (0.33) | — | |
| SCHEMBL3634211 | 0.70 | SLC18A3 (0.49) | HTR2BQDPRALDH1A1TDP1CNR1 | |
| SCHEMBL19988362 | 0.70 | HTR2B (0.64) | HTR2BALDH1A1NAMPT | |
| SCHEMBL17395616 | 0.69 | QDPR (0.46) | HTR2BQDPRTLR9TLR8TLR7 | |
| SCHEMBL13593558 | 0.69 | TPSAB1 (0.52) | TPSAB1 | |
| SCHEMBL19097553 | 0.68 | QDPR (0.55) | HTR2BQDPRALDH1A1TDP1TLR9 | |
| SCHEMBL31706149 | 0.68 | TLR9 (0.48) | HTR2BALDH1A1TDP1TLR9TLR8 | |
| SCHEMBL3634210 | 0.68 | PARP10 (0.55) | HTR2BMCHR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL19097560 | 0.68 | QDPR (0.54) | HTR2BQDPRCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106470985-A | Indane and indoline derivatives as soluble guanylate cyclase activators and uses thereof | 诺华股份有限公司 | 2017-03-01 | — | — | CN | disclosed |