Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2814452 | 0.95 | SMN1; SMN2 (0.41) | MAPTSMN1; SMN2TLR7ALDH1A1ACHE | |
| SCHEMBL2810354 | 0.94 | MAPT (0.39) | MAPTSMN1; SMN2TLR7ALDH1A1ACHE | |
| SCHEMBL2812219 | 0.92 | MAPT (0.42) | MAPTSMN1; SMN2ALDH1A1ACHEBACE1 | |
| SCHEMBL2809631 | 0.91 | MAPT (0.37) | MAPTSMN1; SMN2TLR7ALDH1A1ACHE | |
| SCHEMBL2816710 | 0.91 | EHMT2 (0.43) | MAPTSMN1; SMN2ALDH1A1EHMT2KMT2A | |
| SCHEMBL2813950 | 0.90 | OGA (0.40) | MAPTSMN1; SMN2ALDH1A1ACHEBACE1 | |
| SCHEMBL2808272 | 0.89 | ACHE (0.46) | TLR7ACHEBACE1EHMT2KMT2A | |
| SCHEMBL2809955 | 0.88 | MAPT (0.37) | MAPTSMN1; SMN2TLR7ALDH1A1EHMT2 | |
| SCHEMBL2814240 | 0.87 | ACHE (0.39) | MAPTTLR7ALDH1A1ACHEBACE1 | |
| SCHEMBL2811021 | 0.86 | BCHE (0.40) | MAPTTLR7ACHEBACE1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343983-B2 | Substituted pyrazolo-pyrimidine compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | DPYD, TYMP, TP53 | MAPT 2947/4885SMN1; SMN2 2524/4885TLR7 3602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.