Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.43 |
| ▸ | DNMT3A | Q9Y6K1 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | EED | O75530 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | TACR2 | P21452 | 2/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HLA-A | P04439 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2814452 | 0.96 | SMN1; SMN2 (0.41) | EHMT2DNMT3ASMN1; SMN2MAPTADORA3 | |
| SCHEMBL2812219 | 0.93 | MAPT (0.42) | EHMT2SMN1; SMN2MAPTADORA3MEN1 | |
| SCHEMBL2812911 | 0.91 | MAPT (0.38) | EHMT2SMN1; SMN2MAPTADORA3MEN1 | |
| SCHEMBL2810354 | 0.90 | MAPT (0.39) | EHMT2SMN1; SMN2MAPTMEN1MLNR | |
| SCHEMBL2809631 | 0.89 | MAPT (0.37) | EHMT2SMN1; SMN2MAPTADORA3MEN1 | |
| SCHEMBL2813950 | 0.89 | OGA (0.40) | SMN1; SMN2MAPTMEN1OPRM1KMT2A | |
| SCHEMBL2809538 | 0.88 | EHMT2 (0.41) | EHMT2DNMT3AKCNH2SMN1; SMN2EED | |
| SCHEMBL2808272 | 0.88 | ACHE (0.46) | EHMT2DNMT3AHRH1MEN1KMT2A | |
| SCHEMBL2811021 | 0.87 | BCHE (0.40) | EHMT2MAPTMEN1KMT2A | |
| SCHEMBL2814240 | 0.87 | ACHE (0.39) | EHMT2MAPTMEN1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343983-B2 | Substituted pyrazolo-pyrimidine compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | DPYD, TYMP, TP53 | EHMT2 3441/4885DNMT3A 2966/4885KCNH2 3461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.