Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | YES1 | P07947 | 2/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12826469 | 0.83 | RAB9A (0.64) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL27658585 | 0.81 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2KDRPDGFRB | |
| SCHEMBL400452 | 0.78 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2KDRPDGFRB | |
| SCHEMBL3194098 | 0.73 | RAB9A (0.55) | NPC1RAB9ASMN1; SMN2KDRPDGFRB | |
| SCHEMBL29194186 | 0.72 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2KDRPDGFRB | |
| SCHEMBL5225670 | 0.72 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2KDRPDGFRB | |
| SCHEMBL1550600 | 0.72 | TLR9 (0.87) | NPC1RAB9ASMN1; SMN2KDRPDGFRB | |
| SCHEMBL13541764 | 0.72 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2KDRPDGFRB | |
| SCHEMBL28760253 | 0.72 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2KDRPDGFRB | |
| SCHEMBL30846535 | 0.72 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2KDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458934-B | Quinoxaline compounds and application thereof | 米伦纽姆医药公司 | 2019-08-16 | — | — | CN | disclosed |
| CN-106458934-A | Quinoxaline compounds and uses thereof | 米伦纽姆医药公司 | 2017-02-22 | — | — | CN | disclosed |