Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PDE4A | P27815 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL27368847 | 0.95 | HIF1A (0.67) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27291765 | 0.95 | HIF1A (0.67) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27963342 | 0.90 | HIF1A (0.60) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Benzene SCHEMBL27478517 | 0.89 | — | — | |
| Piperazine SCHEMBL27452555 | 0.86 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27906538 | 0.84 | — | — | |
| Piperazine SCHEMBL28116810 | 0.82 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Benzene SCHEMBL28714782 | 0.82 | CXCR4 (0.75) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL576335 | 0.78 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL2373879 | 0.78 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036028-A | anti-IL 1-RAP antibodies | 塞勒兰特治疗公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-108780094-A | The diagnostic method of use condition active antibodies | 生物蛋白有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-106459960-A | Conditionally active biological proteins | 生物蛋白有限公司 | 2017-02-22 | — | — | CN | disclosed |