Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL3157728 | 0.87 | — | — | |
| Methyl Alcohol SCHEMBL28324348 | 0.87 | HIF1A (0.67) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27368847 | 0.87 | HIF1A (0.67) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27291765 | 0.87 | HIF1A (0.67) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28129606 | 0.82 | HIF1A (0.60) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27963342 | 0.82 | HIF1A (0.60) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Benzene SCHEMBL27478517 | 0.82 | — | — | |
| Aziridine SCHEMBL8129199 | 0.82 | — | — | |
| Piperazine SCHEMBL27713827 | 0.79 | ALDH1A1 (0.38) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27452555 | 0.78 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108366999-A | The method for treating developmental disorder using meratran | 奥维德医疗公司 | 2018-08-03 | — | — | CN | disclosed |
| CN-103025357-B | Selectively deliver compositions and the method for the most specific neural metaclass of oligonucleotide molecules | NLIFE THERAPEUTICS, S.L. (ES) | 2016-12-14 | — | — | CN | disclosed |