Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 5/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28006179 | 0.86 | GFER (0.55) | GFERCASP6HRH3MAPTALDH1A1 | |
| SCHEMBL28631027 | 0.86 | HRH3 (0.47) | HRH3MAPTALDH1A1POLBCYP2C9 | |
| SCHEMBL26123821 | 0.86 | HRH3 (0.47) | HRH3MAPTALDH1A1POLBCYP2C9 | |
| SCHEMBL28379144 | 0.85 | POLB (0.52) | HRH3MAPTALDH1A1POLBCYP2C9 | |
| SCHEMBL23887597 | 0.82 | GFER (0.48) | GFERCASP6HRH3MAPTALDH1A1 | |
| SCHEMBL29225367 | 0.82 | GFER (0.48) | GFERCASP6HRH3MAPTALDH1A1 | |
| SCHEMBL28641422 | 0.81 | GFER (0.43) | GFERCASP6HRH3MAPTALDH1A1 | |
| SCHEMBL11976987 | 0.81 | MAPT (0.69) | GFERCASP6HRH3MAPTALDH1A1 | |
| SCHEMBL20483697 | 0.81 | HRH3 (0.50) | HRH3MAPTPOLBCYP2C9CYP2C19 | |
| SCHEMBL23300904 | 0.81 | MAPT (0.69) | MAPTALDH1A1LMNAPOLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106543143-B | A kind of novel FLT3 kinase inhibitor and application thereof | 合肥中科普瑞昇生物医药科技有限公司 | 2019-03-22 | — | — | CN | disclosed |
| CN-106543143-A | New FLT3 kinase inhibitors of one class and application thereof | 合肥中科普瑞昇生物医药科技有限公司 | 2017-03-29 | — | — | CN | disclosed |