SCHEMBL28137151

SCHEMBL28137151

[CH2]CNC(=O)c1ccc(-c2ccc(CC)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLK1 P53350 1/20 0.58
TAOK1 Q7L7X3 5/20 0.52
TAOK3 Q9H2K8 4/20 0.52
ALDH1A1 P00352 4/20 0.50
TDP1 Q9NUW8 1/20 0.50
TAS1R3 Q7RTX0 1/20 0.49
TAS1R1 Q7RTX1 1/20 0.49
LMNA P02545 3/20 0.48
MAPK1 P28482 1/20 0.48
NLRP1 Q9C000 1/20 0.48
EPHX2 P34913 1/20 0.47
NR1H4 Q96RI1 1/20 0.47
HDAC3 O15379 1/20 0.46
HDAC4 P56524 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC2 Q92769 1/20 0.46
HDAC10 Q969S8 1/20 0.46
HDAC11 Q96DB2 1/20 0.46
HDAC8 Q9BY41 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1742301 0.80 NPC1 (0.60) LMNAMAPK1EPHX2NR1H4HDAC3
SCHEMBL401468 0.80 PLK1 (0.63) PLK1ALDH1A1TDP1HDAC3HDAC4
SCHEMBL10245021 0.80 PLK1 (0.89) PLK1TAOK1TAOK3ALDH1A1TDP1
SCHEMBL404935 0.80 PLK1 (0.54) PLK1TAOK1TAOK3ALDH1A1TDP1
SCHEMBL826023 0.80 PLK1 (0.68) PLK1ALDH1A1TDP1TAS1R3TAS1R1
SCHEMBL14224151 0.79 TAOK1 (0.55) PLK1TAOK1TAOK3ALDH1A1TDP1
SCHEMBL19579516 0.78 EPHX2 (0.56) PLK1EPHX2NR1H4HDAC3HDAC4
SCHEMBL6360077 0.77 PLK1 (0.63) PLK1ALDH1A1TDP1TAS1R3TAS1R1
SCHEMBL10576894 0.77 MAPT (0.63) ALDH1A1TDP1NPC1RAB9AHPGD
SCHEMBL23512343 0.76 ALDH1A1 (0.58) PLK1TAOK1TAOK3ALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107021895-A Antiseptic 尔察祯有限公司 2017-08-08 CN disclosed
CN-101765585-B Antibacterial agent 尔察祯有限公司 2017-03-15 CN disclosed