Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28296832 | 0.90 | PIK3CD (0.50) | FGFR4PIK3CDPIK3CATDO2KCNA5 | |
| SCHEMBL28139444 | 0.88 | FGFR4 (0.44) | FGFR4PIK3CDPIK3CATDO2TGFBR1 | |
| SCHEMBL28138785 | 0.84 | PIK3CD (0.44) | FGFR4PIK3CDPIK3CATDO2TGFBR1 | |
| SCHEMBL28873343 | 0.83 | TGFBR1 (0.48) | FGFR4PIK3CDPIK3CATDO2KCNA5 | |
| SCHEMBL15637895 | 0.81 | TGFBR1 (0.43) | FGFR4PIK3CDPIK3CATDO2TGFBR1 | |
| SCHEMBL15637813 | 0.81 | PIK3CD (0.45) | FGFR4PIK3CDPIK3CATDO2TGFBR1 | |
| SCHEMBL30117539 | 0.81 | PIK3CD (0.45) | FGFR4PIK3CDPIK3CATDO2TGFBR1 | |
| SCHEMBL18069431 | 0.80 | PIK3CA (0.52) | FGFR4PIK3CDPIK3CATDO2EGFR | |
| SCHEMBL28138748 | 0.80 | MAP4K4 (0.46) | FGFR4PIK3CDPIK3CATDO2TGFBR1 | |
| SCHEMBL28138760 | 0.80 | PIK3CA (0.50) | FGFR4PIK3CDPIK3CATDO2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837832-B | GDF-8 inhibitors | 里格尔药品股份有限公司 | 2019-04-26 | — | — | CN | claimed |
| CN-104837832-B | GDF-8 inhibitors | 里格尔药品股份有限公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-106536507-A | 2,3-disubstituted pyridine compounds as TGF-beta inhibitors and methods of use | 里格尔药品股份有限公司 | 2017-03-22 | — | — | CN | disclosed |